PIP5K3 Protein(P17-31G)
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Description :Recombinant human PIP5K3 (1493-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :1493-end
Genbank Number :NM_015040
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~ 93 kDa
Gene Aliases :PIKFYVE; CFD; FAB1; PIP5K; FLJ37746; KIAA0981; MGC40423
Scientific Background :PIP5K3 (also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) encodes an enzyme that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. PIP5K3 belongs to a large family of lipid kinases that alter the phosphorylation status of intracellular phosphatidylinositol but also have protein kinase activity (1). PIP5K3 regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. The inhibition of PIP5K3 renders the late endosome/lysosome compartment refractory to fusion with autophagosomes and multivesicular bodies (2).
References :
1. Shisheva, A..et.al: Cloning, characterization, and expression of a novel Zn(2+)-binding FYVE finger-containing phosphoinositide kinase in insulin-sensitive cells. Molec. Cell. Biol. 19: 623-634, 1999.
2. de Lartigue, J.et.al: PIKfyve regulation of endosome-linked pathways. Traffic 10: 883-893, 2009.
Product Sheets (By Lot #) :
Research Areas :AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Lipid Kinases, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling, Cancer, Neurobiology, Inflammation, Metabolic Disorder, Cardiovascular Disease, AKT/PKB Pathway, NfkB Pathway, WNT Signaling, Apoptosis/Autophagy, Angiogenesis, Invasion/Metastasis, Lipid Kinases