p73 alpha Protein(P08-30G)
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Description :Full-length recombinant human p73 alpha was expressed by baculovirus in Sf9 cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :NM_005427
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~110 kDa
Gene Aliases :TP73, TAp73alpha
Scientific Background :p73α is a member of the p53 family of transcription factors that are involved in cellular responses to stress and development. P73 has high sequence similarity to p53 and p63, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. P73 is a stress-response gene and a downstream effector in the p53 pathway (1). The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. p73 is the components of a mismatch repair-dependent apoptosis pathway which contributes to cisplatin-induced cytotoxicity (2).
References :
1. Wang, J. et.al: p73 is a downstream target of p53 in controlling the cellular defense against stress. J. Biol. Chem. 282: 29152-29162, 2007.
2. Gong, J. et.al: The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature 399: 806-809, 1999.
Product Sheets (By Lot #) :
Research Areas :Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Inflammation, JNK/SAPK Pathway, Metabolic Disorder, Neurobiology, p38 Pathway, Cancer, Neurobiology, Inflammation, Metabolic Disorder, Cardiovascular Disease, p38 Pathway, JNK/SAPK Pathway, Apoptosis/Autophagy, Cell Cycle, Cellular Stress