NRBP1 Protein(N24-34G)
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Description :Recombinant full-length human NRBP1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :BC001221
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :92 kDa
Gene Aliases :BCON3, MADM, MUDPNP
Scientific Background :NRBP1 or nuclear receptor binding protein 1 is a putative adaptor protein which is highly expressed in testis and placenta and lowest levels in hippocampus and thymus (1). The expression of NRBP1 is up-regulated during the progression of prostate cancer and that high NRBP1 expression is linked with poor prognosis and enhanced tumor cell growth (2). NRBP may be an important negative regulator of Jab1-mediated functions such as gene transcription and tumor progression.
References :
1. Hooper, J.D. et.al: Cloning of the cDNA and localization of the gene encoding human NRBP, a ubiquitously expressed, multidomain putative adapter protein. Genomics 66: 113-118, 2000.
2. Ruiz C.et.al: High NRBP1 expression in prostate cancer is linked with poor clinical outcomes and increased cancer cell growth. Prostate. 2012 Nov;72(15):1678-87.
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Research Areas :Cancer, JNK/SAPK Pathway, Cancer, JNK/SAPK Pathway