NFKB2 Protein(N13-31G)
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Description :Recombinant human NFKB2 (1-454) was expressed in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :1-454
Genbank Number :NM_002502
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.gel.gif)
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~84 kDa
Gene Aliases :NFKB2-p52, NFKB2-p100, LYT10, LYT-10
Scientific Background :NFKB2 is a part of the NFKB complex that is present in various cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and disease states. NFKB protein is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products (1). Inappropriate activation of NFKB has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS (2). Overexpression of NFKB2 protects androgen sensitive LNCaP cells from apoptotic cell death and cell cycle arrest induced by androgen-deprivation.
References :
1. Zhu, M. et al: NF-kappa-B2 is required for the establishment of central tolerance through an Aire-dependent pathway. J. Clin. Invest. 116: 2964-2971, 2006.
2. Tucker, E. et al: A novel mutation in the Nfkb2 gene generates an NF-kappa-B2 'super repressor' J. Immun. 179: 7514-7522, 2007.
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Research Areas :AKT/PKB Pathway, Apoptosis/Autophagy, Inflammation, p38 Pathway, Cancer, Inflammation, AKT/PKB Pathway, p38 Pathway, Apoptosis/Autophagy