NFATC1 Protein(N12-30G)
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Description :Recombinant full-length human NFATC1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :NM_172390
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~125 kDa
Gene Aliases :NF-ATC; NFATc; NFAT2; MGC138448
Scientific Background :NFATC1 is a member of the NFAT family of proteins which are Ca2+/calcineurin-responsive transcription factors primarily recognized for their central roles in T lymphocyte activation and cardiac valve development (1). NFAT consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T-cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to the NFAT family of transcription factors play a central role in inducible gene transcription during immune response. The product of NFATC1 is an inducible nuclear component and functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A (2).
References :
1. Buchholz, M. et al: Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway. EMBO. J. 2006; 25(15):3714-24.
2. Jhun, B.S. et al: Inhibition of AMP-activated protein kinase suppresses IL-2 expression through down-regulation of NF-AT and AP-1 activation in Jurkat T cells. Biochem. Biophys. Res. Commun. 2006; 351(4):986-92.
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Research Areas :Inflammation, Cardiovascular Disease, p38 Pathway, JNK/SAPK Pathway, NfkB Pathway, Inflammation, Cardiovascular Disease, p38 Pathway, JNK/SAPK Pathway, NfkB Pathway