MYC Protein(M86-30G)
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Description :Recombinant full-length human MYC was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST
Expression System:Sf9 insect cells using baculovirus
Sequence :Full-length
Genbank Number :P01106-1
Alternative Name(s) :myc proto-oncogene protein; bHLHe39; transcription factor p64
Formulation :Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 25% glycerol.
Storage and Stability :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Scientific Background :MYC (v-myc myelocytomatosis viral oncogene homolog) is a transcription factor that plays a central role in the regulation of cell growth, proliferation, and metabolism. MYC controls the expression of genes involved in the cell cycle, cell growth, and energy metabolism, and its activity is tightly regulated at multiple levels, including transcriptional and post-transcriptional regulation. MYC is activated by a variety of signaling pathways and is overexpressed in many types of cancer, including lymphoma, leukemia, and solid tumors such as breast and lung cancer. MYC is considered as a major oncogene and its overexpression is associated with poor prognosis and resistance to chemotherapy.
References :1. Kreso, A. & Dick, J.E.: MYC, MAX, and MYCN: oncogenes with distinct functions but not overlapping pathways. Nat. Rev. Cancer. 2018, 18(12): 735-751.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Molecular Weight :Observed MW ~88 kDa. Calculated MW ~76 kDa.
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