METTL14 Protein(M334-30G)
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Description :Recombinant full-length human METTL14 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full length
Genbank Number :NM_020961
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Enzyme Function Tests
Molecular Weight :~84 kDa
Gene Aliases :None
Scientific Background :N6-adenosine-methyltransferase subunit METTL14 (Methyl-transferase-like protein 14 or METTL14) methylates adenosine residues of some mRNAs and acts as a regulator of the circadian clock and differentiation of embryonic stem cells. N6-methyladenosine (m6A), which takes place at the 5'-[AG] GAC-3' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing, processing and mRNA stability.
References :
1. http://www.uniprot.org/uniprot/Q9HCE5
2. Liu J, et al: METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Nat Chem Biol. 10(2):93-5, 2014.
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Research Areas :Neurobiology