ERK4 (MAPK4) Protein(M30-34G)
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Description :Full-length recombinant human ERK4 (MAPK4) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full length
Genbank Number :NM_002747
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay
Molecular Weight :~110 kDa
Gene Aliases :MAPK4; ERK3; p63MAPK; PRKM4
Scientific Background :Extracellular signal-regulated kinase 4 (ERK4) is a serine/threonine protein kinase and belongs to atypical MAPKs. Among MAPKs, it is most closely related to the MAP kinase ERK3, with 73% amino acid identity within the kinase catalytic domain. The precise role of ERK4 is still unclear. It phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5, and may promote entry in the cell cycle.
References :
1. Rousseau J, et al. Targeted inactivation of Mapk4 in mice reveals specific nonredundant functions of Erk3/Erk4 subfamily mitogen-activated protein kinases. Mol Cell Biol. 30:5752-63, 2010
2. Kostenko S, et al. Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5. J Mol Signal. 7:9, 2012.
Product Sheets (By Lot #) :
Research Areas :Ser/Thr Kinases, Neurobiology, Invasion/Metastasis, ERK/MAPK Pathway, Cardiovascular Disease, Cancer, Apoptosis/Autophagy, Angiogenesis