MEF2A Protein(M20-34G)
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Description :Recombinant full-length human MEF2A was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST
Expression System:Sf9 insect cells using baculovirus
Sequence :Full-length
Genbank Number :Q02078
Alternative Name(s) :MEF2A; myocyte enhancer factor 2A; myocyte-specific enhancer factor 2A; serum response factor-like protein 1; MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A); mef2; ADCAD1; RSRFC4; RSRFC9
Formulation :Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 25% glycerol.
Storage and Stability :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Scientific Background :MEF2A (Myocyte Enhancer Factor 2A) is a transcription factor that belongs to the Myocyte Enhancer Factor 2 (MEF2) family of proteins. MEF2A plays a crucial role in the regulation of gene expression during cell growth and differentiation, particularly in muscle cells. It is activated by various signaling pathways, including the calcineurin/NFAT pathway, and binds to the MEF2-binding element (MBE) in the promoter region of target genes to promote their transcription. MEF2A has been implicated in a variety of physiological processes, including muscle development and function, cardiovascular development, and neural development. Dysregulation of MEF2A has been observed in various types of cancer, including breast cancer, and it has been proposed as a potential therapeutic target.
References :1. Olson, T.M. & Arnett, J.L.: MEF2 transcription factors: regulators of diverse developmental processes. Dev. Biol. 2009, 328(2): 153-162.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Molecular Weight :Observed MW ~95 kDa. Calculated MW ~88 kDa.
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