MEK6 (MAP2K6), Unactive (M07-14H)
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Description :Recombinant full-length human MEK6 was expressed in E.coli cells using an N-terminal his tag.
Species :Human
Tag :His tag
Expression System:E.coli
Sequence :Full length
Genbank Number :NM_002758
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :38 kDa
Gene Aliases :MAP2K6, MEK6, MAPKK6, PRKMK6, SAPKK3, SKK3
Scientific Background :Mitogen-acitvated protein kinase kinase 6 (MEK6) belongs to the serine/threonine protein kinase family and the MAPK kinase subfamily (MAP2K, MKK or MEKs). MAPKs require dual phosphorylation on threonine and tyrosine residues, an activation step carried out by MAPK kinase (1). MEK6 is a dual-specificity protein kinase that activates p38 MAPK. MEK6 phosphorylates p38 MAP kinase at its activation site Thr-Gly-Tyr and this stimulates the ability of p38 MAPK to phosphorylate protein substrates such as ATF-2 and Elk-1. MEK6 is activated by different forms of cellular stress and inflammatory cytokines (2). Activation of MEK6 occurs via phosphorylation of Ser207 and Thr211 on MEK6 by upstream protein kinases.
References :
1. Dérijard, B. et al: Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science. 1995; 269(5220):17.
2. Han, J. et al. Characterization of the structure and function of a novel MAP kinase kinase (MEK6). J. Biol. Chem. 1996;271(6):2886-91.
Product Sheets (By Lot #) :
Research Areas :Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases