IDO1 Protein (I211-30G)
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Description : Full-length recombinant human IDO1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species : Human
Tag : GST tag
Expression System : Sf9 insect cells using baculovirus
Sequence : Full length
Genbank Number : BC027882
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Western Blot
Molecular Weight : ~68 kDa
Gene Aliases : CD107B, IDO, INDO
Scientific Background : IDO1 encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine which acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. IDO1 play a main role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. IDO1 activity in tumor cells may act to impair antitumor responses (1). The efficacy of therapeutic vaccination of cancer patients might be improved by concomitant administration of an IDO inhibitor (2).
References :
1. Logan, G. J. et.al: HeLa cells cocultured with peripheral blood lymphocytes acquire an immuno-inhibitory phenotype through up-regulation of indoleamine 2,3-dioxygenase activity. Immunology 105: 478-487, 2002.
2. Uyttenhove, C.et.al: Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. Nature Med. 9: 1269-1274, 2003.
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Research Areas : Cell Cycle, Inflammation, Metabolic Disorder,