HEMK1 Protein(H311-30G)
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Description :Recombinant full-length human HEMK1 protein was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full-length
Genbank Number :NM_016173
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Methyltransferase Assay
Molecular Weight :65 kDa
Gene Aliases :HEMK; MTQ1
Scientific Background :HEMK1 belongs to the HemK methyltransferase family, members of which are found in genomes from bacteria to humans (1). HEMK1 methylates the glutamine residue in the GGQ motif of HMRF1L, a human mitochondrial release factor, and plays an important regulatory role in translation termination process (2).
Scientific Background :HEMK1 belongs to the HemK methyltransferase family, members of which are found in genomes from bacteria to humans (1). HEMK1 methylates the glutamine residue in the GGQ motif of HMRF1L, a human mitochondrial release factor, and plays an important regulatory role in translation termination process (2).
References :
1. Bujnicki, J.M., et al. Is the HemK family of putative S-adenosylmethionine-dependent methyltransferases a "missing" zeta subfamily of adenine methyltransferases? A hypothesis. IUBMB Life. 48(3):247-9, 1999.
2. Shizawa, T., et al. The human mitochondrial translation release factor HMRF1L is methylated in the GGQ motif by the methyltransferase HMPrmC. Biochem Biophys Res Commun. 373(1):99-103, 2008.
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Research Areas :Metabolic Disorder