HSD17B10 Protein(H23-30G)
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Description :Recombinant full-length human HSD17B10 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :NM_004493
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~51 kDa
Gene Aliases :ABAD, ERAB, HCD2, MHBD, HADH2, SCHAD, 17b-HSD10
Scientific Background :HSD17B10 gene encodes the protein 17-beta-hydroxysteroid dehydrogenase 10 that is a member of the short-chain dehydrogenase/reductase superfamily SCHAD (1). HSD17B10 gene product is a mitochondrial protein that is involved in lipid metabolism, fatty acid oxidation and steroid hormone metabolism. HSD17B10 protein has been implicated in the development of Alzheimer's disease and mutations in the gene are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD). Furthermore, HSD17B10 may act as a direct molecular link between beta-amyloid and mitochondrial toxicity (2).
References :
1. Yang, S.-Y. et al: Multiple functions of type 10 17-beta-hydroxysteroid dehydrogenase. Trends Endocr. Metab. 16: 167-175, 2005.
2. Lustbader, J. W. et al: ABAD directly links A-beta to mitochondrial toxicity in Alzheimer's disease. Science 304: 448-452, 2004.
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Research Areas :Neurobiology, Cellular Stress, Neurobiology, Cellular Stress