H11 (HSP22) Protein(H09-34G)
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Description :Full-length recombinant human H11 (HSP22) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :NM_014365
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~50 kDa
Gene Aliases :HSP22; CRYAC; CMT2L; DHMN2; E2IG1; HSPB8; HMN2; HMN2A; PP1629
Scientific Background :H11 or heat shock 22kDa protein 8 belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of H11 is induced by estrogen in estrogen receptor-positive breast cancer cells, and H11 also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. H11 is involved in regulation of cell proliferation, apoptosis, and carcinogenesis (1). H11 also causes motor neuron-specific neurite degeneration (2).
References :
1. Benndorf, R.et.al: Shocking degeneration. Nature Genet. 36: 547-548, 2004.
2. Irobi, J.et.al: Mutant HSPB8 causes motor neuron-specific neurite degeneration. Hum. Molec. Genet. 19: 3254-3265, 2010.
Product Sheets (By Lot #) :
Research Areas :AKT/PKB Pathway, Apoptosis/Autophagy, Cardiovascular Disease, Cell Cycle, Cellular Stress, Metabolic Disorder, Neurobiology, NfkB Pathway, Metabolic Disorder, Cardiovascular Disease, AKT/PKB Pathway, NfkB Pathway, Apoptosis/Autophagy, Cell Cycle