HIF1B Protein(H07-30BG)
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Description :Full-length recombinant human HIF1B was expressed by baculovirus in Sf9 cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full length
Genbank Number :NM_001668
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :120 kDa
Gene Aliases :ARNT; bHLHe2; HIF-1-beta; HIF-1beta; HIF1-beta; HIF1BETA; TANGO
Scientific Background :The transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT), alternatively named Hypoxia-inducible factor (HIF)-1β, is part of the Hypoxia-inducible factor (HIF) pathway which mediates cellular adaptations to hypoxia and promotes tumour progression. Unlike HIF-1α that is regulated in an oxygen-dependent manner, HIF-1β is constitutively expressed. It has been shown that some tumour cells are capable to elevate HIF-1β in response to hypoxia to for a clonal advantage. HIF-1β binds HIF-1α, and forms the transcriptional active HIF-1 complex in the nucleus.
References :
1. Mandl M, et al: (2015). The expression level of the transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT) determines cellular survival after radiation treatment. Radiat Oncol. 16;10:229.
2. Mandl M, et al (2013): Hypoxia-inducible factor-1β (HIF-1β) is upregulated in a HIF-1α-dependent manner in 518A2 human melanoma cells under hypoxic conditions. Biochem Biophys Res Commun. 26;434(1):166-72.
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Research Areas :Cancer, Cellular Stress