GRB7 Protein (G45-30GG)
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Description : Recombinant full-length human GRB2 was expressed in E. coli cells using an N-terminal GST tag.
Species : Human
Tag : GST tag
Expression System : E.coli
Sequence : Full length
Genbank Number : NM_001030002
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Western Blot
Molecular Weight : ~91 kDa
Gene Aliases : B47
Scientific Background : GRB7 or growth factor receptor-bound protein 7 belongs to a small family of adapter proteins which interact with a number of receptor tyrosine kinases and signaling molecules. GRB7 encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. GRB7 is highly expressed in liver and kidney (1). GRB7 isoforms are involved in cell invasion and metastatic progression of human esophageal carcinomas (2). GRB7 plays an important role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK).
References :
1. Skolnik, E. Y. et.al: Cloning of PI3 kinase- associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases. Cell 65: 83-90, 1991.
2. Tanaka, S. et.al: A novel variant of human Grb7 is associated with invasive esophageal carcinoma. J. Clin. Invest. 102: 821-827, 1998.
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Research Areas : Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, JAK/STAT Pathway, Neurobiology,