GRK4 Protein(G02-31G)
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Description :Recombinant human GRK4 (140-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :140-end
Genbank Number :BC117320
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~75 kDa
Gene Aliases :GPRK2L, GPRK4, GRK4a, IT11
Scientific Background :GRK4 or G protein-coupled receptor kinase 4 is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family which phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation and it also play an important role in receptor desensitization. GRK4 protein has kinase activity and that it interacts with and is inhibitable by calmodulin (1).GRK4 has been linked to both genetic and acquired hypertension. GRK4 is highly expressed in testis (2).
References :
1. Sallese, M.et.al: G protein-coupled receptor kinase GRK4: molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells. J. Biol. Chem. 272: 10188-10215, 1997.
2. Premont, R. T. et.al: Characterization of the G protein-coupled receptor kinase GRK4: identification of four splice variants. J. Biol. Chem. 271: 6403-6410, 1996.
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Research Areas :ERK/MAPK Pathway, Cardiovascular Disease, Cancer, Ser/Thr Kinases, Neurobiology, Metabolic Disorder, Invasion/Metastasis, Angiogenesis