EPHB6 Protein(E26-35G)
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Description :Recombinant human EPHB6 (617-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :617-end
Genbank Number :NM_004445
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~70 kDa
Gene Aliases :HEP; Mep
Scientific Background :EPHB6 or EPH receptor B6 is a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins which can influence cell adhesion and migration.EPHB6 is downregulated during tumor progression which may suppress tumor invasion and metastasis. EPHB6 also play pivotal roles in neural and cardiovascular development and expressed in different subsets of neuroblastoma (1). EPHB6 is also crucial for T-cell function (2).
References :
1. Tang, X. X.et.al: Implications of EPHB6, EFNB2, and EFNB3 expressions in human neuroblastoma. Proc. Nat. Acad. Sci. 97: 10936-10941, 2000.
2. Luo, H.et.al: EphB6-null mutation results in compromised T cell function. J. Clin. Invest. 114: 1762-1773, 2004.
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Research Areas :Angiogenesis, Cancer, Cardiovascular Disease, Neurobiology, Receptor Tyrosine Kinases, Cancer, Neurobiology, Cardiovascular Disease, Angiogenesis, Receptor Tyrosine Kinases