DPYSL2 Protein (D470-30BG)
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Description : Full-length recombinant human DPYSL2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species : Human
Tag : GST tag
Expression System : Sf9 insect cells using baculovirus
Sequence : Full length
Genbank Number : BC056408
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Western Blot
Molecular Weight : ~89 kDa
Gene Aliases : CRMP2, DHPRP2, DRP-2, DRP2
Scientific Background : Dihydropyrimidinase-related protein 2 (DPYSL2) is express-ed in both the CNS and PNS, playing a key role in neuronal development, axonal and neuronal growth, cell migration, and protein trafficking. Disruptions of DPYSL2 function have been implicated in neurodegenerative disorders such as Alzheimer's disease, neuropathic pain, and Batten disease, and to psychiatric disorders such as schizophrenia.
References :
1. Martins-de-Souza D, et al. The protein interactome of collapsin response mediator protein-2 (CRMP2/DPYSL2) reveals novel partner proteins in brain tissue. Proteomics Clin Appl. 9: 817-31, 2015.
2. Liu Y, et al. Functional variants in DPYSL2 sequence increase risk of schizophrenia and suggest a link to mTOR signaling. G3 (Bethesda). 5:61-72, 2014.
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Research Areas : AKT/PKB Pathway, Neurobiology,