Cyclin E2 Protein(C82-30BG)
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Description :Recombinant full-length human CyclinE2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full length
Genbank Number :NM_057749
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :72 kDa
Gene Aliases :CCNE2; CYCE2
Scientific Background :CCNE2 is belongs to the cyclin family, Cyclin E subfamily. It is encoded by a separate gene from Cyclin E1, but shows substantial amino acid sequence similarity. Like Cyclin E1, it binds and activates the cyclin-dependent kinase 2 (Cdk2), which in turn phosphorylates proteins involved in cell cycle progression such as pRB, p107, NPM1, MCMs, thereby driving cell proliferation. A defect in spermatogenesis is the only phenotype observed in cyclin E2-deficient mice, suggesting its role in male fertility.
References :
1. Geng Y, et al. (2003) Cyclin E ablation in the mouse. Cell 114: 431–443.
2. Hwang HC, et al. (2005) Cyclin E in normal and neoplastic cell cycles. Oncogene 24: 2776–2786.
3. Odajima J, et al. (2016). Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo. PLoS Genet. 12(11):e1006429.
Product Sheets (By Lot #) :
Research Areas :Cancer, Cell Cycle