CRKL Protein(C53-30H)
FOR BULK ORDER REQUESTS PLEASE CONTACT US
Description :Recombinant full length human CRKL was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Species :Human
Tag :HIS tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :NM_005207
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~39kDa
Gene Aliases :crk-like protein
Scientific Background :CRKL or v-crk sarcoma virus CT10 oncogene homolog (avian)-like is a protein kinase containing SH2 and SH3 (src homology) domains that activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion (1). It is a substrate of the BCR-ABL tyrosine kinase which plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic (2). CRKL is also required for normal cellular responses to Fgf8, including survival and migration, Erk activation, and target gene expression.
References :
1. Ten Hoeve.J et.al: Isolation and chromosomal localization of CRKL, a human crk-like gene. Oncogene 8: 2469-2474, 1993.
2. Senechal, K. et.al: The CRKL adaptor protein transforms fibroblasts and functions in transformation by the BCR-ABL oncogene. J. Biol. Chem. 38: 23255-23261, 1996.
Product Sheets (By Lot #) :
Research Areas :Apoptosis/Autophagy, Cancer, Cell Cycle, Receptor Tyrosine Kinases, WNT Signaling, Cancer, WNT Signaling, Apoptosis/Autophagy, Cell Cycle, Receptor Tyrosine Kinases