CDKL3 Protein(C45-30G)
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Description :Recombinant full-length human CDKL3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :NM_001113575
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~98 kDa
Gene Aliases :NKIAMRE
Scientific Background :CDKL3 or cyclin-dependent kinase-like 3 is a member of cyclin-dependent protein kinase (CDK) family which is highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and is known to be important regulators of cell cycle progression and cellular proliferation. CDKL3 is a novel CDC2-related kinase with features of both mitogen-activated protein kinases and cyclin-dependent kinases (1). CDKL3 is identified as a gene absent in leukemic patients with chromosome 5q deletion and this loss may be an important determinant of dysmyelopoiesis (2).
References :
1. Yee, K. W. L. et.al: NKIAMRE, a novel CDC2-related kinase with features of both mitogen-activated protein kinases and cyclin-dependent kinases. Biochem. Biophys. Res. Commun. 308: 784-792, 2003.
2. Midmer, M. et.al: Identification of NKIAMRE, the human homologue to the mitogen-activated protein kinase-/cyclin-dependent kinase-related protein kinase NKIATRE, and its loss in leukemic blasts with chromosome arm 5q deletion. Cancer Res. 59: 4069-4074, 1999.
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Research Areas :Cancer, Cell Cycle, Ser/Thr Kinases, Cancer, Cell Cycle, Ser/Thr Kinases