Cofilin 1 Protein(C37-54H)
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Description :Recombinant full-length human Cofilin 1 was expressed in E. coli cells using an N-terminal His tag.
Species :Human
Tag :HIS tag
Expression System:E.coli
Sequence :Full Length
Genbank Number :NM_005507
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.gel.gif)
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~23 kDa
Gene Aliases :CFL1, CFL
Scientific Background :Cofilin 1 (non-muscle), also known as CFL1, is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner (1). It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus (2). CFL1 processed proteins are most probably produced by HIV-1 protease digestion.
References :
1. Maciver, S.K. et al: The ADF/cofilin family: actin-remodeling proteins.". Genome Biol. 2002; 3 (5): reviews 3007.
2. Samstag, Y. Et al: Iteraction of cofilin with the serine phosphatases PP1 and PP2A in normal and neoplastic human T lymphocytes.". Adv. Enzyme Regul. 2004;97–211.
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Research Areas :Cancer, Neurobiology, Cardiovascular Disease, Invasion/Metastasis, Cancer, Neurobiology, Cardiovascular Disease, Invasion/Metastasis