CDK13/CyclinK Active (C25-11BG)
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Description :Recombinant human CDK13 (516-end) /Cyclin K complex was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag on both proteins.
Species :Human
Tag :GST tags
Expression System:Sf9 insect cells using baculovirus
Sequence :CDK13 (658-end) and Cyclin K (Full Length)
Genbank Number : NM_003718
Genbank Number 2 : BC015935
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Specific Activity:
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight : CDK13 approx. MW 160kDa and CyclinK Approx. MW 67kDa.
Gene Aliases : CDK13: CDC2L; CDC2L5; CHED; hCDK13 CyclinK: CCNK, CPR4, MGC9113
Scientific Background : CDK13 or cyclin-dependent kinase 13 is a member of the cyclin-dependent serine/threonine protein kinase family which are well known for their essential roles as master switches in cell cycle control. CDK13 forms a complex with cyclin K and is predicted to play a role in gene regulation (1). CDK13 may play a role in mRNA processing and is thought to be involved in regulation of hematopoiesis (2). The CYCK-CDK12 and CYCK-CDK13 complexes display unique function in cell cycle and gene regulation.
References :
- Blazek, D.et.al: The cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes. Genes Dev. 25: 2158-2172, 2011.
- Lapidot-Lifson, Y.et.al: Cloning and antisense oligodeoxynucleotide inhibition of a human homolog of cdc2 required in hematopoiesis. Proc. Nat. Acad. Sci. 89: 579-583, 1992.
Product Sheets (By Lot #) : J3908-7
Research Areas :Cancer, Cell Cycle, Ser/Thr Kinases, Cancer, Cell Cycle, Ser/Thr Kinases