CDK20 (CCRK) Protein(C21-30G)
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Description :Full-length recombinant mouse CDK20 (CCRK) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Mouse
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :NM_053180
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~64 kDa
Gene Aliases :CCRK; CDCH; PNQLARE; p42; MGC38901
Scientific Background :CDK20 or cyclin-dependent kinase 20 contains a kinase domain most closely related to the cyclin-dependent protein kinases which may activate cyclin-dependent kinase 2 and is involved in cell growth. CDK20 is a monomeric CAK that specifically phosphorylates CDK2 thr160 and functions as a CDK2-activating kinase. CDK20 is also a novel cyclin-dependent kinase-activating kinase in mammalian cells (1). CDK20 depletion inhibits glioblastoma cell proliferation in a cilium-dependent manner (2).
References :
1. Liu, Y.et.al: p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells. J. Biol. Chem. 279: 4507-4514, 2004.
2. Yang Y. et.al: CRK depletion inhibits glioblastoma cell proliferation in a cilium-dependent manner. EMBO Rep. 2013 Aug;14(8):741-7
Product Sheets (By Lot #) :
Research Areas :Cancer, Cell Cycle, Ser/Thr Kinases, Cancer, Cell Cycle, Ser/Thr Kinases