Catenin alpha Protein(C05-30G)
FOR BULK ORDER REQUESTS PLEASE CONTACT US
Description :Recombinant full-length human Catenin alpha was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :NM_001903
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~123 kDa
Gene Aliases :CTNNA1, CAP102, FLJ36832
Scientific Background :Catenin α is a novel actin-binding and -bundling protein. Catenin α is responsible for organizing and tethering actin filaments at the zones of E-cadherin-mediated cell-cell contact (1). Monomeric Catenin α can bind strongly to E-Cadherin-β-Catenin, whereas the dimer preferentially binds actin filaments. Different molecular conformations are associated with these different binding states, indicating that Catenin α is an allosteric protein. Catenin α directly regulates actin-filament organization by suppressing Arp2/3-mediated actin polymerization, likely by competing with the Arp2/3 complex for binding to actin filaments (2)
References :
1. Rimm, D L. etal: Alpha 1(E)-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex. Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8813-7.
2. Drees, F. et al: Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. Cell. 2005 Dec 2;123(5):903-15.
Product Sheets (By Lot #) :
Research Areas :Cancer, Neurobiology, Cardiovascular Disease, PKA/PKC Pathway, WNT Signaling, Invasion/Metastasis, Cancer, Neurobiology, Cardiovascular Disease, PKA/PKC Pathway, WNT Signaling, Invasion/Metastasis