BAG1 Protein (B05-31G)
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Description : Recombinant human BAG1 (72-end) was expressed in E. coli cells using an N-terminal GST tag.
Species : Human
Tag : GST tag
Expression System : E.coli
Sequence : 72-end
Genbank Number : NM_004323
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Western Blot
Molecular Weight : ~66 kDa
Gene Aliases : RAP46
Scientific Background : BAG1 (also known as BCL2-associated athanogene) is a membrane protein rich in glutamic acid residues that binds to BCL2 and blocks apoptosis or programmed cell death (1). The BAG1-BCL2 complex enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms (2). Overexpression of BAG1 in 3T3 fibroblasts prevents apoptosis in the presence of low serum. BAG1 has also been shown to interact with activated glucocorticoid, androgen, estrogen and progesterone receptors. Binding to these receptors by BAG1 is dependent on receptor activation.
References :
1. Tang, S.C. BAG-1, an anti-apoptotic tumour marker.". IUBMB Life, 2003; 53 (2): 99–105.
2. Clemo, N.K. et al: The role of the retinoblastoma protein (Rb) in the nuclear localization of BAG-1: implications for colorectal tumour cell survival.". Biochem. Soc. Trans.2005; 33 (Pt 4): 676–8.
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Research Areas : AKT/PKB Pathway, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Neurobiology,