ASH2L Protein(A372-30BG)
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Description :Full-length recombinant human ASH2L was expressed in E. coli cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:E.coli
Sequence :Full length
Genbank Number :BC015936
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Methyltransferase Assay
Molecular Weight :~94 kDa
Gene Aliases :ASH2L2
Scientific Background :Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2L) is part of MLL complexes, consisting of one of seven Set/MLL proteins (SETA, SETB, MLL1 to 5), ASH2L, RBBP5, WDR5, HDPY-30, and others. Possesses histone methyltransferase activity. Specifically methylates 'Lys-4' of histone H3 when the neighboring 'Lys-9' residue is not methylated.
References :
1. Patel A, et al: On the mechanism of multiple lysine methyla-tion by the human mixed lineage leukemia protein-1 (MLL1) core complex. J Biol Chem. 2009 284(36):24242-56.
2. Qi J, et al: Absent, small or homeotic 2-like protein (ASH2L) enhances the transcription of the estrogen receptor α gene through GATA-binding protein 3 (GATA3). J Biol Chem. 2014 289(45):31373-81.
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Research Areas :Cancer, Neurobiology