ATR Protein(A27-35G)
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Description :Recombinant human ATR (2245-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :2245-end
Genbank Number :NM_001184
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :70 kDa
Gene Aliases :FRP1, MEC1, SCKL, SCKL1
Scientific Background :ATR belongs to the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase which share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. ATR is shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. ATR is an essential regulator of genomic integrity, controls and coordinates DNA-replication origin firing, replication-fork stability, cell cycle checkpoints, and DNA repair (1). ATR/ATM-dependent phosphorylation of RAD17 is a critical early event during checkpoint signaling in DNA-damaged cells (2).
References :
1. Tanaka, A.et.al: Germline mutation in ATR in autosomal-dominant oropharyngeal cancer syndrome. Am. J. Hum. Genet. 90: 511-517, 2012.
2. Bao, S. et.al: ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. Nature 411: 969-974, 2001.
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Research Areas :Apoptosis/Autophagy, Cancer, Cell Cycle, Cellular Stress, ERK/MAPK Pathway, Ser/Thr Kinases, Cancer, ERK/MAPK Pathway, Apoptosis/Autophagy, Cell Cycle, Cellular Stress, Ser/Thr Kinases