ATM Protein(A26-35G)
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Description :Recombinant human ATM (2667-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :2667-end
Genbank Number :NM_000051
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~70 kDa
Gene Aliases :AT1, ATA, ATC, ATD, ATE, ATDC, TEL1, MGC74674
Scientific Background :The Serine/threonine protein kinase ataxia-telangiectasia mutated (ATM) is an atypical kinase of the phosphoinositide 3-kinase (PI3K)-related protein kinase PIKK family, which also includes ATM and Rad3-related protein (ATR), the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs), hSMG1, and mammalian target of rapamycin (mTOR) kinases (1). It plays a prominent role as an apical activator of the DNA damage response under the circumstance of DNA double-strand breaks (DSBs). Following induction of DSBs, ATM mobilizes one of the most extensive signaling networks that responds to specific stimuli and modifies directly or indirectly a broad range of targets (2).
References :
1. Lempiäinen H, Halazonetis TD. Emerging common themes in regulation of PIKKs and PI3Ks. EMBO J. 2009 Oct 21;28(20):3067-73.
2. Shiloh Y, Ziv Y. The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. Nat Rev Mol Cell Biol. 2013 Apr;14(4):197-210.
Product Sheets (By Lot #) :
Research Areas :Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Inflammation, Lipid Kinases, Metabolic Disorder, Ser/Thr Kinases