TPM3 Protein(T36-30H)
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Description :Full-length recombinant human TPM3 protein was expressed in E.coli cells using an N-terminal His tag.
Species :Human
Tag :His tag
Expression System:E.coli
Sequence :Full length
Genbank Number :NM_152263
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~39 kDa
Gene Aliases :APM1; CFTD; hscp30; NEM1; OK/SW-cl.5; TM-5; TM3; TM30; TM30nm; TM5; TPMsk3
Scientific Background :TPM3 or tropomyosin 3 is a member of the tropomyosin family of actin-binding proteins that are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. TPM3 involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. TPM3 protein is substituted for the external domain of a putative tyrosine-kinase cell surface receptor to create the TRK oncogene (1). TPM3 are a common cause of congenital fiber type disproportion (2).
References :
1. Coulier, F.et.al: Mechanism of activation of the human TRK oncogene. Molec. Cell. Biol. 9: 15-23, 1989.
2. Clarke, N. F. et.al: Mutations in TPM3 are a common cause of congenital fiber type disproportion. Ann. Neurol. 63: 329-337, 2008.
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Research Areas :Cancer, Cancer