PYK2, Active(P92-11H)
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Description :Recombinant human PYK2 (360-690) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Species :Human
Tag :HIS tag
Expression System:Sf9 insect cells using baculovirus
Sequence :360-690
Genbank Number :NM_004103
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~39 kDa
Gene Aliases :FAK2, PTK2B, CADTK, FADK2, CAKB, PKB, PTK, RAFTK, PYK2
Scientific Background :PYK2 (also known as FAK2/RAFTK) is a member of the focal adhesion PTK family. PYK2/FAK2 can be activated by a variety of extracellular signals that elevate intracellular calcium concentration, and by stress signals (1). Unlike FAK, which is widely expressed in various tissues and links transmembrane integrin receptors to intracellular pathways, PYK2/FAK2 is expressed mainly in the central nervous system and in cells derived from hematopoietic lineages. In osteoclasts, although FAK is expressed, PYK2/FAK2 appears to be the predominant mediator of integrin alpha(v)beta3 signaling events that influence osteoclast physiology and pathology (2).
References :
1. Avraham, H. et al: RAFTK/Pyk2-mediated cellular signalling. Cell Signal. 2000 Mar;12(3):123-33.
2. Xiong, W C. et al: PYK2 and FAK in osteoclasts. Front Biosci. 2003 Sep 1;8:d1219-26.
Product Sheets (By Lot #) :
Research Areas :Cancer, Neurobiology, Inflammation, Cardiovascular Disease, ERK/MAPK Pathway, JAK/STAT Pathway, Invasion/Metastasis, Cytoplasmic Tyrosine Kinases, Cancer, Neurobiology, Inflammation, Cardiovascular Disease, ERK/MAPK Pathway, JAK/STAT Pathway, Invasion/Metastasis, Cytoplasmic Tyrosine Kinases