JNK1, Active(M33-10G)
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Description :Recombinant full-length mouse JNK1 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Species :Mouse
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :NM_016700
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet. 
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~71 kDa
Gene Aliases :JNK; PRKM8; SAPK1; AI849689; JNK1A2; JNK21B1/2
Scientific Background :JNK1 is a member of the MAP kinase group that is activated by dual phosphorylation at thr and tyr residues during exposure to stress such as UV irradiation. JNK1 binds to the c-Jun transactivation domain and phosphorylates it on Ser-63 and Ser-73 (1). JNK1 has been shown to play an important role in disease processes. Activation of JNK1 results in defects in myotube viability and integrity leading to dystrophic myofiber destruction (2). JNK1 activity is also abnormally elevated in obesity and removal of JNK1 results in decreased adiposity and significantly improved insulin sensitivity.
References :
1. Derijard, B. et al: JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell. 1994 Mar 25;76(6):1025-37.
2. Kolodziejczyk, S M. et al: Activation of JNK1 contributes to dystrophic muscle pathogenesis. Curr Biol. 2001 Aug 21;11(16):1278-82.
Cited Publication :
1. Liu. B, et al. ABL-N-induced apoptosis in human breast cancer cells is partially mediated by c-Jun NH2-terminal kinase activation. Breast Cancer Res. 2010, 12(1):R9
Product Sheets (By Lot #) :
Research Areas :Neurobiology, Inflammation, Cardiovascular Disease, JNK/SAPK Pathway, NfkB Pathway, Apoptosis/Autophagy, Cellular Stress, Ser/Thr Kinases, Neurobiology, Inflammation, Cardiovascular Disease, JNK/SAPK Pathway, NfkB Pathway, Apoptosis/Autophagy, Cellular Stress, Ser/Thr Kinases