HCK, Active(H02-11G)
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Description :Recombinant human HCK (230-497) was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :230-497
Genbank Number :NM_002110
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~57 kDa
Gene Aliases :JTK9
Scientific Background :HCK, a protein-tyrosine kinase belonging to the Src family, is expressed in certain hemopoietic cells and especially prominent in cells of myeloid lineage, particularly mature granulocytes and monocytes (1). HCK gene is located on chromosome sequence 20q11-q12, a region that is affected by interstitial deletions in some acute myeloid leukemias and myeloproliferative disorders suggesting damage to HCK may contribute to the pathogenesis of these conditions (2).
References :
1. Ziegler, S F. et al: Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin. Molec. Cell. Biol. 7: 2276-2285, 1987.
2. Quintrell, N. et al: Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells. Molec. Cell. Biol. 7: 2267-2275, 1987
Product Sheets (By Lot #) :
Research Areas :Cancer, Inflammation, Metabolic Disorder, JAK/STAT Pathway, Cytoplasmic Tyrosine Kinases, Cancer, Inflammation, Metabolic Disorder, JAK/STAT Pathway, Cytoplasmic Tyrosine Kinases