FLT4, Active(F13-11G)
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Description :Recombinant human FLT4 (800-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :800-end
Genbank Number :NM_002020
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~85 kDa
Gene Aliases :VEGFR3; FLT41; LMPH1A; PCL
Scientific Background :FLT4 or fms-related tyrosine kinase 4 is a tyrosine kinase receptor for vascular endothelial growth factors C and D and highly expressed in lymphangiogenesis and maintenance of the lymphatic endothelium. FLT4 is a marker for lymphatic vessels and some high endothelial venules in human adult tissues and also supported the theory of the venous origin of lymphatic vessels (1). FLT4 plays an essential role in the development of the embryonic cardiovascular system before the emergence of the lymphatic vessels (2).
References :
1. Kaipainen, A. et.al: Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development. Proc. Nat. Acad. Sci. 92: 3566-3570, 1995.
2. Dumont, D. J. et..al: Cardiovascular failure in mouse embryos deficient in VEGF receptor-3. Science 282: 946-949, 1998.
Product Sheets (By Lot #) :
Research Areas :AKT/PKB Pathway, Angiogenesis, Cancer, ERK/MAPK Pathway, Receptor Tyrosine Kinases, Cancer, AKT/PKB Pathway, ERK/MAPK Pathway, Angiogenesis, Receptor Tyrosine Kinases