EIF2AK4 (GCN2), Active(E12-11G)
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Description :Recombinant human EIF2AK4 (192-1024) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :192-1024
Genbank Number :NM_001013703
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~132 kDa
Gene Aliases :GCN2; KIAA1338
Scientific Background :EIF2AK4 or eukaryotic translation initiation factor 2 alpha kinase 4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 to downregulate protein synthesis in response to varied cellular stresses (1). The EIF2AK4 eIF2-alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid (2).
References :
1. Berlanga, J. J. et.al: Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2-alpha kinase. Europ. J. Biochem. 265: 754-762, 1999.
2. Guo, F. et.al: The GCN2 eIF2-alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid. Cell Metab. 5: 103-114, 2007.
Product Sheets (By Lot #) :
Research Areas :Angiogenesis, Cellular Stress, Inflammation, Neurobiology, Ser/Thr Kinases, Neurobiology, Inflammation, Cellular Stress, Angiogenesis, Ser/Thr Kinases