PRKY Protein(P82-35G)
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Description :Recombinant human PRKY (40-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :40-end
Genbank Number :BC074852
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~53 kDa
Gene Aliases :None
Scientific Background :PRKY or protein kinase, Y-linked, pseudogene is a novel serine/threonine subtype of protein kinase that appears to encode a protein related to the catalytic subunit of the cAMP-dependent protein kinases which are key players in the cellular responses to the second messenger cAMP. PRKY gene is classified as a transcribed pseudogene because it has lost a coding exon that results in all transcripts being candidates for nonsense-mediated decay (NMD) and unlikely to express a protein (1). Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females (2).
References :
1. Schiebel, K.et.al: FISH localization of the human Y-homolog of protein kinase PRKX (PRKY) to Yp11.2 and two pseudogenes to 15q26 and Xq12-q13. Cytogenet. Cell Genet. 76: 49-52, 1997.
2. Schiebel, K.et.al: Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females. Hum. Molec. Genet. 6: 1985-1989, 1997.
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Research Areas :PKA/PKC Pathway, NfkB Pathway, Neurobiology, Metabolic Disorder, Invasion/Metastasis, Inflammation, ERK/MAPK Pathway, Cardiovascular Disease, Neurobiology, Inflammation, Metabolic Disorder, Cardiovascular Disease, ERK/MAPK Pathway, NfkB Pathway, PKA/PKC Pathway, Apoptosis/Autophagy, Invasion/Metastasis, Ser/Thr Kinases