LMTK2 Protein(L07-35G)
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Description :Recombinant human LMTK2 (66-583) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :66-583
Genbank Number :NM_014916
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~96 kDa
Gene Aliases :AATYK2; BREK; cprk; KPI-2; KPI2; LMR2; KIAA1079
References :
1. Wang, H.et.al: A novel transmembrane ser/thr kinase complexes with protein phosphatase-1 and inhibitor-2. J. Biol. Chem. 277: 49605-49612, 2002.
2. Kikuno, R.et.al: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 6: 197-205, 1999.
Scientific Background :LMTK2 or lemur tyrosine kinase belongs to the protein kinase superfamily and the protein tyrosine kinase family which contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. LMTK2 can associate with PPP1CA and PPP1R2 to form a membrane-localized regulatory complex (1). LMTK2 is highly expressed in all specific adult brain regions, particularly in thalamus, amygdala, cerebellum, and caudate nucleus (2). LMTK2 protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking.sine kinase 2.
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Research Areas :Cancer, Ser/Thr Kinases, Cancer, Ser/Thr Kinases