PTC1 (CCDC6-RET), Active(R02-19BG)
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Description :Recombinant human RET/PTC1, the fusion protein [CCDC6 (1-101)-RET (713-end)], was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :CCDC6 (1-101)-RET (713-end)
Genbank Number :BC036757
Genbank Number 2 :NM_020630
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~80 kDa
Gene Aliases :CCDC6: H4, PTC, TPC RET: CDHF12, RET51, PTC, RET-ELE1; RET/PTC1
References :
1. Grieco M. et al: PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas. Cell 1990, 60:557-563.
2. Nikiforov YE: RET/PTC rearrangement in thyroid tumors. Endocr Pathol 2002, 13:3-16.
3. Smida J. et al: Distinct frequency of ret rearrangements in papillary thyroid carcinomas of children and adults from Belarus. Int J Cancer 1999, 80:32-38.
Scientific Background :RET/PTC1 is fused of RET and the activating CCDC6 gene by intrachromosomal paracentric inversions in chromo-some 10 (1). Likes RET/PTC3, it is the most frequent RET rearrangements in papillary thyroid carcinoma (PTC) (2), especially in radiation-induced tumours. The RET/PTC1 rearrangements may be a marker for later-occurring PTC of radiation-exposed children and adults (3). The RET/PTC rearrangements also have been shown in benign thyroid lesions, including Hashimoto's thyroiditis (HT).
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Research Areas :Cancer, Cancer, Neurobiology, Metabolic Disorder, Cell Cycle, Cellular Stress