TRKC (G696A), Active (N18-12FH)
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Description :Recombinant human TRKC (G696A) (454-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Species :Human
Tag :His tag
Expression System:Sf9 insect cells using baculovirus
Sequence :454-end (G696A)
Genbank Number :NM_001012338
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay
Molecular Weight :45 kDa
Gene Aliases :NTRK3, gp145 (trkC)
Scientific Background :TRKC is a member of the TRK family of tyrosine kinase receptors and is the high affinity catalytic receptor for the neurotrophin NT-3 (neurotrophin-3). TRKC mediates the multiple cellular effects of the NT-3 neurotrophic factor, which includes neuronal differentiation and survival (1). TRKC has been implicated in insulin signaling pathway through interactions with the MUSK protein receptor and the VEGF receptor. Mutations in the TRKC gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers (2).
References :
1. Lamballe, F. et al: trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3". Cell, 1991; 66 (5): 967–79.
2. Marchetti, A. et al: Frequent mutations in the neurotrophic tyrosine receptor kinase gene family in large cell neuroendocrine carcinoma of the lung. Hum Mutat. 2008 May;29(5):609-16.
Product Sheets (By Lot #) :
Research Areas :Receptor Tyrosine Kinases, Neurobiology