c-MER (A708S), Active(M51-12BG)
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Description :Recombinant human c-MER (A708S) (578-872) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :578-872 (A708S)
Genbank Number :NM_006343
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay
Molecular Weight :~58 kDa
Gene Aliases :MERTK
Scientific Background :c-MER is a member of the TYRO3/AXL/MER (TAM) receptor kinase family which encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Cytokine-dependent activation of TAM signaling diverts a proinflammatory pathway to provide an intrinsic feedback inhibitor of both TLR- and cytokine-driven immune responses (1). c-MER is essential regulators of mammalian spermatogenesis (2). Mutations in c-MER gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).
References :
1. Rothlin, C. V.et.al: TAM receptors are pleiotropic inhibitors of the innate immune response. Cell 131: 1124-1136, 2007.
2. Lu, Q.et.al: Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. Nature 398: 723-728, 1999.
Product Sheets (By Lot #) :
Research Areas :Receptor Tyrosine Kinases, Inflammation, Cardiovascular Disease, Cancer, Neurobiology, Inflammation, Cytoplasmic Tyrosine Kinases