c-KIT (Y823D), Active(K06-12GG)
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Description :Recombinant human c-KIT (Y823D) (544-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :544-end (Y823D)
Genbank Number :NM_000222
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay
Molecular Weight :~73 kDa
Gene Aliases :PBT, SCFR, CD119
Scientific Background :c-KIT (Y823D) encodes the ligand-binding chain (alpha) of the gamma interferon receptor which is a heterodimer of IFNGR1 and IFNGR2. c-KIT (Y823D) is a regulator of hematopoietic stem cells during homeostasis and under conditions of infectious stress. A genetic variation in c-KIT (Y823D) is associated with susceptibility to Helicobacter pylori infection. In addition, defects in c-KIT (Y823D) are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection (1). c-KIT (Y823D is also associated with the clinical outcome of HBV infection in Chinese adults (2).
References :
1. Baldridge, M. T. et.al: Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection. Nature 465: 793-797, 2010.
2. Zhou, J. et.al: A regulatory polymorphism in interferon-gamma receptor 1 promoter is associated with the susceptibility to chronic hepatitis B virus infection. Immunogenetics 61: 423-430, 2009.
Product Sheets (By Lot #) :
Research Areas :Receptor Tyrosine Kinases, Neurobiology, Inflammation, Cancer