FGFR1OP-FGFR1, Active(F04-19BG)
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Description :Recombinant human fusion protein FGFR1OP (1-173)-FGFR1 (429-end) was expressed by baculovirus in Sf9 cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :1-173 (FGFR1OP) 429-end (FGFR1)
Genbank Number :BC011902
Genbank Number 2 :NM_023110
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay
Molecular Weight :108 kDa
Gene Aliases :FGFR1OP: FOP FGFR1: FLT2, CEK, FLG, KAL2, BFGFR, C-FGR, CD331, N-SAM
Scientific Background :FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family that constitute a family of four membrane-spanning tyrosine kinases (FGFR1-4) which serve as high-affinity receptors for 17 growth factors (FGF1-17). The FGF Receptor family plays an important role in multiple biological processes, including mesoderm induction and patterning, cell growth and migration, organ formation and bone growth (1). FGFR1 is alternatively spliced generating multiple splice variants that are differentially expressed during embryo development and in the adult body (2).
References :
1. Xu, X. et al: Fibroblast growth factor receptors (FGFRs) and their roles in limb development. Cell Tissue Res. 1999 Apr;296(1):33-43.
2. Groth, C. et al: The structure and function of vertebrate fibroblast growth factor receptor 1. Int J Dev Biol. 2002;46(4):393-400.
Product Sheets (By Lot #) :
Research Areas :Cancer, Receptor Tyrosine Kinases, Cancer, AKT/PKB Pathway, ERK/MAPK Pathway, Angiogenesis, Receptor Tyrosine Kinases