SUV39H2 (KMT1B), Active(S350-380BG)
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Description :Recombinant full-length human SUV39H2 (KMT1B) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full length
Genbank Number :BC007754
Specific Activity :Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet._P1545-6activity.gif)
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Methyltransferase Assay
Molecular Weight :67 kDa
Gene Aliases :KMT1B; FLJ23414
Scientific Background :Homo sapiens suppressor of variegation 3-9 homolog 2 (SUV39H2) is encoded by the SUV39H2 gene and belongs to the histone-lysine methyltransferase family and Suvar3-9 subfamily, It contains an N-terminal chromodomain and a C-terminal SET domain. It trimethylates lysine 9 of histone H3, creating a binding site for the chromo domain of HP1 for epigenetic transcriptional repression. Deregulation of SUV39H2 interferes with mammalian higher-order chromatin organization.
References :
1. Rea S, et al: Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature.10;406(6796):593-9, 2000.
2. Aagaard L, et al: Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the hetero-chromatin component M31. EMBO J. 1;18(7):1923-38, 1999.
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Research Areas :Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology