SMYD2 (KMT3C), Active(S348-380BG)
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Description :Recombinant full-length human SMYD2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full length
Genbank Number :BC049367
Specific Activity :Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet._I085-2activity.gif)
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Methyltransferase Assay
Molecular Weight :70 kDa
Gene Aliases :KMT3C; HSKM-B; ZMYND14
Scientific Background :SMYD2 (also known as SET and MYND domain-containing protein 2) is a member of the SMYD family of protein methyltransferases. SMYD2 is also known as lysine methyltransferase protein 3C (KMT3C). SMYD2 functions to repress transcription by interacting with the Sin3A histone deacetylase complex and performs methylation of Lys36 in histone H3 (1). The exogenous expression of SMYD2 in mouse fibroblasts decreases cell growth. SMYD2 also function as a putative oncogene by methylating p53 and repressing its tumor suppressive function (2).
References :
1. Brown, M. A. et.al: Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex. Molec. Cancer 5: 26, 2006.
2. Huang, J. et.al: Repression of p53 activity by Smyd2-mediated methylation. Nature 444: 629-632, 2006.
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Research Areas :Apoptosis/Autophagy, Cancer, Cell Cycle, Inflammation, Neurobiology