JMJD6 Protein(J453-30G)
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Description :Recombinant full-length human JMJD6 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full length
Genbank Number :BC066654
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~75 kDa
Gene Aliases :PSR, PTDSR1
Scientific Background :Jumonji domain-containing 6 protein (JMJD6) encodes a bifunctional arginine demethylase and lysyl-hydroxylase that displays dual activities as a histone arginine demethylase and a lysyl-hydroxylase. It demethylates histone H3 at arginine 2 (H3R2) and histone H4 at arginine 3 (H4R3). Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65.
References :
1. Chang B, et al. JMJD6 is a histone arginine demethy-lase. Science. 2007 Oct 19; 318(5849):444-7.
2. Webby CJ, et al. Jmjd6 catalyzes lysylhydroxylation of U2AF65, a protein associated with RNA splicing. Science. 2009 Jul 3;325(5936):90-3.
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Research Areas :Angiogenesis, Cancer