USP46, Protein (U546-30H)
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Description : Recombinant full-length human USP46 was expressed in E. coli cells using an N-terminal his tag.
Species : Human
Tag : His tag
Expression System : E. coli cells
Sequence : Full length
Genbank Number : NM_022832
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Western Blot
Molecular Weight : 44 kDa
Gene Aliases : Ubiquitin specific peptidase 46
Scientific Background : The ubiquitin-specific protease 46 (USP46) belongs to the ubiquitin-specific protease family, a subfamily of deubiquitinating enzymes (DUBs) (1). USP46 requires the interaction with WDR48 to have a higher activity than by its own (2). The expression of USP46 is associated with PHLPP in colorectal patient cancer specimens and USP46 serves as a stabilizer of PHLPP via the suppression of Akt signaling pathway in colon cancer cells (3).
References :
1. Quesada V, et al. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. Biochem Biophys Res Commun. 2004 Jan 30; 314(1):54-62.
2. Yin J, et al. Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46. Structure. 2015 Nov 3; 23(11):2043-54.
3. Li X, et al. The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer. Oncogene. 2013 Jan 24; 32(4):471-8.
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Research Areas : Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder