UCHL5, Active (U526-380H)
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Description : Recombinant full length human UCHL5, was expressed in E. coli cells using an N-terminal His tag.
Species : Human
Tag : His tag
Expression System : E.coli
Sequence : Full length
Genbank Number : NM_001199261
Specific Activity : Sample Activity Plot. For specific information on a given lot, see related technical data sheet. 
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Activity Assay, Western Blot
Molecular Weight : 38 kDa
Gene Aliases : UCH-L5, UCH37, CGI-70, INO80R
Scientific Background : UCHL5 (Ubiquitin carboxyl-terminal hydrolase isozyme L5) is a member of the peptidase C12 family of deubiquitinating enzymes and specially cleaves 'Lys-48'-linked polyubiquitin chains. UCHL5 is associated with the 19S regulatory subunit of the 26S proteasome and may play a role as a putative regulatory component of the INO80 complex (1). High expression of UCHL5 has also been indicated to be correlated with increased disease-specific survival in lymph-node-positive rectal cancer, suggesting that it could be a possible novel prognostic marker (2).
References :
1. Yao, T.T. et al: Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. Molecular cell 31(6): 909-17, 2008.
2. Arpalahti, L. et al: UCHL5 expression associates with improved survival in lymph-node-positive rectal cancer. Tumor Biology: 1-8, 2017.
Product Sheets: (by Lot #):
Research Areas : Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder