USP11, Active (U511-380G)
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Description : Recombinant full-length human USP11 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species : Human
Tag : GST tag
Expression System : Sf9 insect cells using baculovirus
Sequence : Full length
Genbank Number : NM_004651
Specific Activity : Sample Activity Plot. For specific information on a given lot, see related technical data sheet. 
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Activity Assay, Western Blot
Molecular Weight : 136 kDa
Gene Aliases : UHX1
Scientific Background : USP11 (ubiquitin carboxyl-terminal hydrolase 11) is a member of the ubiquitin specific proteases family (USPs) and is a protease that functions in the removal of conjugated ubiquitin from target proteins and polyubiquitin chains. The enzyme cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains and is involved in regulating pathways that lead to NF-kappa-B activation by regulating IκB kinase α (1). USP11 also binds to p21, a cyclin-dependent kinase inhibitor and plays an important role in regulating cell-cycle progression and DNA damage responses.
References :
1. Yamaguchi, T. et al. The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha). J Biol Chem. 282(47):33943-8, 2007.
2. Tanggang, D. et al: Deubiquitylation and stabilization of p21 by USP11 is critical for cell-cycle progression and DNA damage responses. Proceedings of the National Academy of Sciences 115(18): 4678-4683, 2018.
Product Sheets: (by Lot #):
Research Areas : Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder