SHIP1, Active(P08-20G)
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Description :Recombinant full length human SHIP1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full length
Genbank Number :NM_005541
Specific Activity :Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Phosphatase Assay, Western Blot
Molecular Weight :144~160 kDa
Gene Aliases :INPP5D, SHIP, hp51CN, SIP-145, MGC142140, MGC142142
Scientific Background :The SH2-containing inositol-5′-phosphatase, SHIP or SHIP1, is a hematopoietic-specific phosphatidylinositide phosphatase. It is recruited to the plasma membrane after extracellular stimulation and hydrolyzes the phosphatidylinositol-3-kinase-generated second messen-ger PI-3,4,5-P3 to PI-3,4-P2, downregulating PI-3,4,5-P3-mediated signaling and represses the proliferation, differentiation, survival, activation, and migration of hematopoietic cells. It has been shown that SHIP1 may act as a tumor suppressor during leukemogenesis and lymphomagenesis.
References :
1. Hamilton MJ, et al: Role of SHIP in cancer. Exp Hematol. 39(1):2-13, 2011.
2. Kavanaugh WM, et al: Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2. Current Biology. 6:438–445, 1996.
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Research Areas :Inflammation, Cancer, Apoptosis/Autophagy, Lipid Kinases, AKT/PKB Pathway